| 19.08.2018 | Sampdoria–Fiorentina | 1–1 | 15:00 |
| 26.08.2018 | Fiorentina – Chievo | 5–1 | 20:30 |
| 02.09.2018 | Fiorentina– Udinese | 1–0 | 15:00 |
| 16.09.2018 | Napoli – Fiorentina | 1–0 | 18:00 |
| 22.09.2018 | Fiorentina – Spal | 3–0 | 18:00 |
| 25.09.2018 | Inter – Fiorentina | 2–1 | 20:30 |
| 30.09.2018 | Fiorentina – Atalanta | 2–0 | 15:00 |
| 07.10.2018 | Lazio – Fiorentina | 1–0 | 15:00 |
| 21.10.2018 | Fiorentina – Cagliari | 1–1 | 18:00 |
| 27.10.2018 | Torino – Fiorentina | 1–1 | 20:30 |
| 03.11.2018 | Fiorentina – Roma | 1–1 | 18:00 |
| 09.11.2018 | Frosinone – Fiorentina | 1–1 | 20:30 |
| 25.11.2018 | Bologna – Fiorentina | 0–0 | 15:00 |
| 01.12.2018 | Fiorentina – Juventus | 0–3 | 18:00 |
| 09.12.2018 | Sassuolo – Fiorentina | 3–3 | 12:30 |
| 16.12.2018 | Fiorentina – Empoli | 3–1 | 15:00 |
| 22.12.2018 | Milan – Fiorentina | 0–1 | 15:00 |
| 26.12.2018 | Fiorentina – Parma | 0-1 | 15:00 |
| 29.12.2018 | Genoa – Fiorentina | 0–0 | 15:00 |
Girone di Ritorno
| 20.01.2019 | Fiorentina-Sampdoria | 3–3 | 15:00 |
| 27.01.2019 | Chievo – Fiorentina | 3–4 | 12:30 |
| 03.02.2019 | Udinese – Fiorentina | 1–1 | 15:00 |
| 09.02.2019 | Fiorentina – Napoli | 0–0 | 18:00 |
| 17.02.2019 | Spal – Fiorentina | 1–4 | 12.30 |
| 24.02.2019 | Fiorentina – Inter | 3–3 | 20:30 |
| 03.03.2019 | Atalanta –Fiorentina | 3–1 | 18:00 |
| 10.03.2019 | Fiorentina – Lazio | 1–1 | 20:30 |
| 15.03.2019 | Cagliari – Fiorentina | 2–1 | 15:00 |
| 31.03.2019 | Fiorentina – Torino | 1–1 | 15:00 |
| 03.04.2019 | Roma – Fiorentina | 2–2 | 21:00 |
| 07.04.2019 | Fiorentina-Frosinone | 0–1 | 12:30 |
| 14.04.2019 | Fiorentina– Bologna | 0–0 | 15:00 |
| 20.04.2019 | Juventus – Fiorentina | 2–1 | 18:00 |
| 29.04.2019 | Fiorentina – Sassuolo | 0–1 | 21:00 |
| 05.05.2019 | Empoli – Fiorentina | 1–0 | 12:30 |
| 11.05.2019 | Fiorentina– Milan | 0–1 | 20:30 |
| 19.05.2019 | Parma – Fiorentina | 1–0 | 15:00 |
| 26.05.2019 | Fiorentina – Genoa | 0–0 | 15:00 |